CNTA insider transactions

Large owner Medicxi Ventures Management (Jersey) Ltd sold 19,963,157 units of Ordinary Shares (SEC Form 4) to cover taxes

Large owner Index Ventures Life Vi (Jersey) L.P. sold 9,961,789 units of Ordinary Shares (SEC Form 4) (withholding obligation)

Chief People Officer Anderson Karen M. returned 62,085 units of Ordinary Shares to the company, closing all direct ownership in the company (SEC Form 4) to cover taxes

Chief Technology & Quality Ofc Bush Tia L returned 147,954 units of Ordinary Shares to the company, closing all direct ownership in the company (SEC Form 4) (withholding obligation)

Director Goyal Arjun returned 462,585 units of Ordinary Shares to the company (SEC Form 4) (tax liability)

Chief Executive Officer Accardi Mario Alberto returned 243,282 units of Ordinary Shares to the company, closing all direct ownership in the company (SEC Form 4) (withholding obligation)

Chief Legal Officer Hussain Iqbal J returned 123,145 units of Ordinary Shares to the company, closing all direct ownership in the company (SEC Form 4) (tax withholding)

Chief Financial Officer Crowley John J returned 45,000 units of Ordinary Shares to the company, closing all direct ownership in the company (SEC Form 4) to satisfy tax liability

Chief Accounting Officer Deferiere Raphael returned 11,000 units of Ordinary Shares to the company, closing all direct ownership in the company (SEC Form 4) to cover taxes

Director De Rubertis Francesco returned 19,963,157 units of Ordinary Shares to the company (SEC Form 4) to satisfy withholding tax

Chief Business Officer Weinhoff Gregory M returned 65,925 units of Ordinary Shares to the company, closing all direct ownership in the company (SEC Form 4) to satisfy withholding tax

Chief Medical Officer Kanes Stephen returned 120,000 units of Ordinary Shares to the company, closing all direct ownership in the company (SEC Form 4) (withholding obligation)

SEC Form 4 filed by Director Hedley Mary Lynne (tax withholding)

SEC Form 4 filed by Director Kulkarni Samarth to cover withholding tax

SEC Form 4 filed by Director Hukkelhoven Mathias (tax withholding)

SEC Form 4 filed by Director Stuckley Carol (withholding tax)

SEC Form 4 filed by Director Zbar Brett I W (for tax liability)

Chief Executive Officer Accardi Mario Alberto covered exercise/tax liability with 604 units of Ordinary Shares, decreasing direct ownership by 0.25% to 243,282 units (SEC Form 4) to cover withholding tax

SEC Form 4 filed by Anderson Karen M.

SEC Form 4 filed by Weinhoff Gregory M

SEC Form 4 filed by Anderson Karen M.

Amendment: Chief People Officer Anderson Karen M. exercised 109,398 units of Ordinary Shares at a strike of $3.99 and sold $3,150,673 worth of Ordinary Shares (120,029 units at $26.25), decreasing direct ownership by 15% to 62,085 units (SEC Form 4)

Chief People Officer Anderson Karen M. exercised 109,398 units of Ordinary Shares at a strike of $4.01 and sold $3,150,673 worth of Ordinary Shares (120,029 units at $26.25), decreasing direct ownership by 15% to 62,085 units (SEC Form 4)

Chief Business Officer Weinhoff Gregory M sold $1,927,131 worth of Ordinary Shares (73,196 units at $26.33), decreasing direct ownership by 53% to 65,925 units (SEC Form 4)

Chief Medical Officer Kanes Stephen was granted 120,000 units of Ordinary Shares (SEC Form 4)

Chief Financial Officer Crowley John J was granted 45,000 units of Ordinary Shares (SEC Form 4)

Chief Accounting Officer Deferiere Raphael was granted 11,000 units of Ordinary Shares (SEC Form 4)

Chief Legal Officer Hussain Iqbal J sold $1,004,918 worth of Ordinary Shares (39,961 units at $25.15), covered exercise/tax liability with 7,780 units of Ordinary Shares and was granted 60,000 units of Ordinary Shares, increasing direct ownership by 12% to 117,645 units (SEC Form 4)

Chief Business Officer Weinhoff Gregory M covered exercise/tax liability with 14,158 units of Ordinary Shares and was granted 31,000 units of Ordinary Shares, increasing direct ownership by 14% to 139,121 units (SEC Form 4)

Chief Executive Officer Accardi Mario Alberto was granted 68,000 units of Ordinary Shares and covered exercise/tax liability with 2,915 units of Ordinary Shares, increasing direct ownership by 36% to 243,886 units (SEC Form 4)

Chief People Officer Anderson Karen M. was granted 29,000 units of Ordinary Shares and covered exercise/tax liability with 10,606 units of Ordinary Shares, increasing direct ownership by 34% to 72,716 units (SEC Form 4)

Chief Technology & Quality Ofc Bush Tia L covered exercise/tax liability with 8,549 units of Ordinary Shares and was granted 35,000 units of Ordinary Shares, increasing direct ownership by 22% to 147,954 units (SEC Form 4)

President, Orexin Program Accardi Mario Alberto sold $288,289 worth of Ordinary Shares (10,000 units at $28.83), decreasing direct ownership by 5% to 178,801 units (SEC Form 4)

President, Orexin Program Accardi Mario Alberto exercised 5,000 units of Ordinary Shares at a strike of $9.53 and sold $300,000 worth of Ordinary Shares (10,000 units at $30.00), decreasing direct ownership by 3% to 188,801 units (SEC Form 4)

General Counsel Hussain Iqbal J exercised 6,000 units of Ordinary Shares at a strike of $5.84 and sold $165,835 worth of Ordinary Shares (6,000 units at $27.64) (SEC Form 4)

Chief Technology & Quality Ofc Bush Tia L exercised 40,000 units of Ordinary Shares at a strike of $9.42 and sold $1,120,000 worth of Ordinary Shares (40,000 units at $28.00) (SEC Form 4)

Chief Technology & Quality Ofc Bush Tia L exercised 40,000 units of Ordinary Shares at a strike of $9.42 and sold $1,040,000 worth of Ordinary Shares (40,000 units at $26.00) (SEC Form 4)

President, Orexin Program Accardi Mario Alberto covered exercise/tax liability with 593 units of Ordinary Shares, decreasing direct ownership by 0.31% to 193,801 units (SEC Form 4)

President, Orexin Program Accardi Mario Alberto exercised 5,000 units of Ordinary Shares at a strike of $8.01 and sold $200,000 worth of Ordinary Shares (8,000 units at $25.00), decreasing direct ownership by 2% to 194,394 units (SEC Form 4)

General Counsel Hussain Iqbal J exercised 6,000 units of Ordinary Shares at a strike of $5.84 and sold $134,439 worth of Ordinary Shares (6,000 units at $22.41) (SEC Form 4)

Chief Technology & Quality Ofc Bush Tia L exercised 35,000 units of Ordinary Shares at a strike of $9.42 and sold $840,000 worth of Ordinary Shares (35,000 units at $24.00) (SEC Form 4)

President, Orexin Program Accardi Mario Alberto sold $174,846 worth of Ordinary Shares (8,172 units at $21.40), decreasing direct ownership by 4% to 197,394 units (SEC Form 4)

General Counsel Hussain Iqbal J exercised 6,000 units of Ordinary Shares at a strike of $5.84 and sold $131,101 worth of Ordinary Shares (6,000 units at $21.85) (SEC Form 4)

Chief Technology & Quality Ofc Bush Tia L exercised 49,792 units of Ordinary Shares at a strike of $8.72 and sold $1,045,840 worth of Ordinary Shares (49,792 units at $21.00) (SEC Form 4)

General Counsel Hussain Iqbal J exercised 40,000 units of Ordinary Shares at a strike of $5.84 and sold $840,102 worth of Ordinary Shares (40,000 units at $21.00) (SEC Form 4)

President, Orexin Program Accardi Mario Alberto exercised 5,000 units of Ordinary Shares at a strike of $8.01 and sold $140,000 worth of Ordinary Shares (7,000 units at $20.00), decreasing direct ownership by 0.96% to 205,566 units (SEC Form 4)

General Counsel Hussain Iqbal J exercised 6,000 units of Ordinary Shares at a strike of $5.84 and sold $103,380 worth of Ordinary Shares (6,000 units at $17.23) (SEC Form 4)

President, Orexin Program Accardi Mario Alberto covered exercise/tax liability with 597 units of Ordinary Shares, decreasing direct ownership by 0.29% to 207,566 units (SEC Form 4)

President, Orexin Program Accardi Mario Alberto sold $126,751 worth of Ordinary Shares (8,322 units at $15.23), decreasing direct ownership by 4% to 208,163 units (SEC Form 4)

Chief Business Officer Weinhoff Gregory M exercised 10,000 units of Ordinary Shares at a strike of $3.85 and sold $155,598 worth of Ordinary Shares (10,000 units at $15.56) (SEC Form 4)

Chief Executive Officer Saha Saurabh exercised 55,000 units of Ordinary Shares at a strike of $3.85 and sold $875,600 worth of Ordinary Shares (55,000 units at $15.92) (SEC Form 4)

General Counsel Hussain Iqbal J exercised 6,000 units of Ordinary Shares at a strike of $5.84 and sold $89,567 worth of Ordinary Shares (6,000 units at $14.93) (SEC Form 4)

Chief Business Officer Weinhoff Gregory M exercised 10,000 units of Ordinary Shares at a strike of $3.85 and sold $138,642 worth of Ordinary Shares (10,000 units at $13.86) (SEC Form 4)

General Counsel Hussain Iqbal J exercised 12,000 units of Ordinary Shares at a strike of $5.84 and sold $168,218 worth of Ordinary Shares (12,000 units at $14.02) (SEC Form 4)

President, Orexin Program Accardi Mario Alberto exercised 15,000 units of Ordinary Shares at a strike of $3.85 and sold $210,000 worth of Ordinary Shares (15,000 units at $14.00) (SEC Form 4)

SEC Form 4 filed by Director Goyal Arjun

SEC Form 4 filed by Director Hedley Mary Lynne

SEC Form 4 filed by Director Hukkelhoven Mathias

SEC Form 4 filed by Director Kulkarni Samarth

SEC Form 4 filed by Director Stuckley Carol